Ion Selectivity in the Selectivity Filters of Acid-Sensing Ion Channels

Ion Selectivity in the Selectivity Filters of Acid-Sensing Ion Channels

Sodium-selective acid sensing ion channels (ASICs), which belong to the epithelial sodium channel (ENaC) superfamily, are key players in many physiological processes (e.g. nociception, mechanosensation, cognition, and memory) and are potential therapeutic targets. Central to the ASIC's function is its ability to discriminate Na(+) among cations, which is largely determined by its selectivity fi...

Dynamic Selectivity Filters in Ion Channels

was permeable to molecules as large as the 630 Da YO-Pasadena, California 91125 PRO-1 dye. This experiment demonstrated, for the first time, real time changes in ion selectivity for a molecularly defined, single ion channel species (but see Petrou et Membrane ion channels contain integral pores that pre-al., 1997). cisely select their permeant ions. This selectivity an-P2X Structure-Function Ba...

Ion conduction and selectivity in acid-sensing ion channel 1

The ability of acid-sensing ion channels (ASICs) to discriminate among cations was assessed based on changes in conductance and reversal potential with ion substitution. Human ASIC1a was expressed in Xenopus laevis oocytes, and acid-induced currents were measured using two-electrode voltage clamp. Replacement of extracellular Na(+) with Li(+), K(+), Rb(+), or Cs(+) altered inward conductance an...

Ion conduction and selectivity in K(+) channels.

Potassium (K(+)) channels are tetrameric membrane-spanning proteins that provide a selective pore for the conductance of K(+) across the cell membranes. These channels are most remarkable in their ability to discriminate K(+) from Na(+) by more than a thousandfold and conduct at a throughput rate near diffusion limit. The recent progress in the structural characterization of K(+) channel provid...

Ion Conduction and Selectivity in K+ Channels